Amlodipine besylate, {2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate} is an antihypertensive drug of dihydropyridine calcium channel blocker class, administered orally as a long acting antihypertensive agent that is used in the treatment of acute and chronic hypertension and as prophylactic treatment of angina pectoris. Fast-dissolving tablets (FDTs) of amlodipine besylate were prepared by direct-compression method. Nine formulae having three subliming agents at three different concentration levels were prepared to assess the most efficiency and critical concentration level. Twelve formulae having three subliming agents at the predetermined level and two superdisintegrants at two different concentration levels were prepared to assess the efficiency of superdisintegrants and their critical concentration level. Six formulae having three subliming agents at the most efficient level and coprocessed superdisintegrant at different concentrations levels were prepared to assess the efficiency of coprocessed superdisintegrants and its critical concentration level. The prepared tablets were evaluated with respect to their shape, size, organoleptic properties, drug content uniformity, weight variation, mechanical strength, water absorption ratio, wetting time, dissolution behavior and disintegration time. All the prepared powder blends showed passable to excellent flowability. The prepared tablets were of acceptable drug content and weight variation according to USP specifications. \r\nTablets containing Camphor (15%) and Ac- Di- Sol (8%) showed superior organoleptic properties, mechanical properties, water absorption ratio, wetting time, along with excellent in-vivo disintegration time and drug release, as compared to other formulae.
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